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Reprogramming CAF and targeting CAF-associated signaling pathways In addition to depleting CAFs via their biomarkers or related proteins, another strategy to target CAFs is to weaken or eliminate their pro-tumorigenic functions
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found that Gyejibongnyeong-Hwan (GBH) induces apoptosis by elevating mitochondrial ROS levels, promoting p53, caspase-3, and caspase-9 expression, and increasing the Bax/Bcl-2 ratio, demonstrating GBH's potential as a therapeutic agent for uterine fibroids [95]
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