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In vascular SMC cultured in vitro , bilirubin reduces the activity of ERK (101), which is a key kinase for entry into the S phase
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MAPK/ERK Cascade and GILZ Homology Computational and molecular research identified structural homology between DSIP and GILZ (glucocorticoid-induced leucine zipper) — a glucocorticoid-regulated protein that prevents Raf-1 activation and thereby inhibits ERK phosphorylation via the MAPK cascade
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