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A study using pilocarpine eyedrops and an ocular therapeutic system
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Knockout of prolyl hydroxylase domain-containing protein 2 (PHD2) stabilized HIF-1ฮฑ protein and activated HIF-1ฮฑ signaling, which transcriptionally upregulated glutaminase 1 ( GLS1 ) expression leading to a decrease in ROS production and increases in cellular GSH levels, GSH/GSSG, and cell survival in murine periosteal progenitor cells, suggesting that HIF-1ฮฑ signaling promotes glutaminolysis to provide glutamate for GSH synthesis (96)
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