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a smaller group aged 20-60 who are right-handed and can safely have an MRI will also be included for brain imaging
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Development of high-throughput (next-generation) sequencing allowed DNA methylome analysis to be more sensitive and less biased than approaches based on enzymatic digestion or methylated DNA immunoprecipitation combined with hybridization to microarrays (for review, see Lister and Ecker (2009))
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