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In vitro, GH-RH stimulated multiple pathways involved in inflammation and growth in both BPH-1 and PrEp cells, including NF-κB p65, AKT, ERK1/2, EGFR, STAT3, and increased the levels of TGF-β1 and the transactivation of the IGF receptor
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In the U.S., CMS guidance from March 2024 allows Medicare Part D coverage of AOMs with medically accepted indications, such as diabetes or reducing the risk of major adverse cardiovascular events in patients with established cardiovascular disease
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