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reported that tumor cells lose resistance to the ferroptosis inducer RAS-selective lethal 3 (RSL3) when they are depleted of FSP1, thereby becoming more susceptible to ferroptosis ( The dihydroorotate dehydrogenase (DHODH) pathway generates reduced coenzyme Q (CoQH 2 ) within the inner mitochondrial membrane, which plays a key role in suppressing ferroptosis
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