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20-hydroxyeicosatetraenoic acid (20-HETE), a metabolite of ADA, was recently shown to be involved in neuronal ferroptosis upon ICH induction in mice ( in vitro model of ICH (Karuppagounder et al., 2018)
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Using a modified Ellman assay with Lineweaver-Burk analysis, BPC-157 was characterized as a reversible competitive inhibitor of acetylcholinesterase with an inhibition constant of 0.48 millimolar, alongside two rationally designed hybrid analogs, CIARA-1 and CIARA-2, at 0.24 and 0.29 millimolar
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