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Unlike the HG-3 and MEC-1 cell lines, the patients’ primary lymphocytes did not respond metabolically to CB-839 given in combination with venetoclax, AZD-5991, or ibrutinib
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In this study, we demonstrate that AML cell death occurring early after APR-246 exposure is suppressed by iron chelators, lipophilic antioxidants and inhibitors of lipid peroxidation, and correlates with the accumulation of markers of lipid peroxidation, thus fulfilling the definition of ferroptosis, a recently described cell death process
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