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Statements Ethics statement The study was ethically approved by the Institutional Ethics committee of Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine
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52 In 2023, the Nobel Prize in Physiology and Medicine was awarded to Katalin Kariko and Drew Weissman for pioneering nucleoside base modification technology to decrease mRNA immunogenicity, further highlighting the critical role of chemical modification technologies in developing mRNA vaccines
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