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There are a few reviews on the immunomodulatory effects of Zingiber species, but a comprehensive update and critical analysis of the studies related to these effects are needed (Harun and Mohamad., 2022
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ECM Remodeling: Collagen, Elastin, GAGs# In dermal fibroblasts, GHK-Cu upregulates type I and III collagen, elastin, decorin, and glycosaminoglycan synthesis while simultaneously activating matrix metalloproteinases (MMP-1, MMP-2) and their tissue inhibitors (TIMPs)
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